454861
MNK1 Inhibitor
4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine
For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
13 February 2012
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A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 244.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C11H9FN6 | ||
| CAS number | 522629-08-9 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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