475863
MK2a Inhibitor
Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2′-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
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EMD Chemicals, Inc.
480 S. Democrat Road
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United States
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13 February 2012
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A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
| Product information | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | Mk2α | ||
| Primary Target Ki | 330 nM | ||
| Molar mass | 349.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C22H20FNO2 | ||
| CAS number | 41179-33-3 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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