176910
Anthrax Lethal Factor Protease Inhibitor III
5-(5-(2-Chloro-5-trifluoromethyl-phenyl)-furan-2-ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl)-acetic acid, BI-11B3
For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
13 February 2012
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This product has been discontinued.
We are currently only offering Anthrax Lethal Factor Protease Inhibitor, In-2-LF (Cat. No. 176901) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A cell-permeable, rhodanine-acetic acid analog that chelates the active site Zn2+ and acts as a potent inhibitor of anthrax lethal factor (LF) metalloproteinase (Ki = 32 nM). Has only a minimal inhibitory effect on MMP-2 and MMP-9. Shown to effectively prevent MAPKK1 proteolysis (< 2 µM) by LF and offer protection against LF and protective antigen (PA) cytotoxic effects in RAW264.7 cells (IC50 < 5 µM). BI-11B3 has been shown to double the survival rates of mice challenged with anthrax spores and treated with ciproflaxin.
| Product information | |||
|---|---|---|---|
| Form | Yellow to orange solid | ||
| Primary Target | anthrax LF metalloprotease | ||
| Primary Target IC50 | 32 nM | ||
| Molar mass | 447.8 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H9ClF3NO4S2 | ||
| CAS number | 259811-62-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
