For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
13 February 2012
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This product has been discontinued.
We apologize for the inconvenience, but we do not currently have an alternative product. Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210bcr-abl phosphorylation in viable K562 cells at concentrations and durations of exposure that also inhibit cell proliferation. Reported to alter the physical state of p210bcr-abl and the association of p210bcr-abl with Shc and Grb2 in K562 cells.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | p210bcr-abl | ||
| Primary Target Ki | 750 nM | ||
| Molar mass | 273.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C15H15NO4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
