For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
15 February 2012
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A cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2 (cPLA2; IC50 = ~20 µM). Specific inhibition of cPLA2 activity by AACOCF3 partially inhibits TNF-induced apoptosis without inhibition of caspase activity. Causes a significant diminution in thromboxane B2 production in thrombin-stimulated platelets. Also inhibits platelet aggregation in response to collagen and arachidonic acid.
| Product information | |||
|---|---|---|---|
| Form | Clear yellow oil | ||
| Primary Target | cPLA2 | ||
| Primary Target IC50 | 20 µM | ||
| Molar mass | 356.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C21H31F3O | ||
| CAS number | 149301-79-1 | ||
| Store and ship information | |||
|---|---|---|---|
|
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Flammable |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed. |
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| R Phrase |
R: 11 Highly flammable. |
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