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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: emdinfo@emdchemicals.com
03 September 2010
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A cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2 (cPLA2; IC50 = ~20 µM). Specific inhibition of cPLA2 activity by AACOCF3 partially inhibits TNF-induced apoptosis without inhibition of caspase activity. Causes a significant diminution in thromboxane B2 production in thrombin-stimulated platelets. Also inhibits platelet aggregation in response to collagen and arachidonic acid.
| Product information | |||
|---|---|---|---|
| Form | Clear yellow oil | ||
| Primary Target | cPLA2 | ||
| Primary Target IC50 | 20 µM | ||
| Molar mass | 356.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C21H31F3O | ||
| CAS number | 149301-79-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
