500090
L(+)Ascorbyl palmitate
(6-palmitoyl-L-ascorbic acid) suitable for use as excipient EMPROVE® exp Ph Eur,BP,NF,FCC,E 304
| Product information | |||
|---|---|---|---|
| Grade | Ph Eur,BP,NF,FCC,E 304 | ||
| Synonyms | Palmitoyl-L-ascorbic acid | ||
| Formula Hill | C22H38O7 | ||
| HS Code | 2936 27 00 | ||
| EC number | 205-305-4 | ||
| Molar mass | 414.54 g/mol | ||
| CAS number | 137-66-6 | ||
| Chemical and physical data | |||
|---|---|---|---|
| Solubility | (20 °C) insoluble | ||
| Melting point | 107 - 117 °C | ||
| Molar mass | 414.54 g/mol | ||
| Boiling point | >250 °C | ||
| Safety information | |||
|---|---|---|---|
| Storage class | 10 - 13 Other liquids and solids | ||
| WGK | WGK 1 slightly water endangering | ||
| Disposal |
3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
||
| Transport information | |||
|---|---|---|---|
| Declaration (railroad and road) ADR, RID | Kein Gefahrgut | ||
| Declaration (transport by sea) IMDG-Code | No Dangerous Good | ||
| Declaration (transport by air) IATA-DGR | No Dangerous Good | ||
| Toxicological data | |||
|---|---|---|---|
| LD 50 oral | LD50 rat > 5000 mg/kg | ||
| Specifications | |
|---|---|
| Assay (iodometric, calc. on dried substance) | 98.0 - 100.5 % |
| Identity - IR-spectrum | conforms |
| - Tillmans-Reaction | conforms |
| Appearance | white or yellowish-white powder |
| Appearance of solution (100 g/l, methanol) | clear and not more intense in colour than colour reference solution BG4 (Ph. Eur.) |
| Melting range - lower value | ≥ 107 °C |
| - upper value | ≤ 117 °C |
| Spec. rotation [α]20/D (100 g/l, Metanol, calc on dried basis) | +21 - +24 ° |
| Spec. rotation [α]25/D (100 g/l, Metanol, calc on dried basis) | +21 - +24 ° |
| Heavy metals (as Pb) | ≤ 0.001 % |
| As (Arsenic) | ≤ 0.0003 % |
| Cu (Copper) | ≤ 0.0025 % |
| Hg (Mercury) | ≤ 0.0001 % |
| Pb (Lead) | ≤ 0.0002 % |
| Zn (Zinc) | ≤ 0.0025 % |
| Methylisobutylketone | ≤ 0.5 % |
| Ethyl acetate | ≤ 0.5 % |
| Other residual solvents (Ph.Eur./USP/ICH) | excluded by production process |
| Sulfated ash (600 °C) | ≤ 0.1 % |
| Loss on drying (5 h, 60 °C, Vacuum) | ≤ 1.0 % |
| Residues of metal catalysts or metal reagents acc.to EMEA/CHMP/SWP/4446/2000 are not likely to be present. | |
| Correspond to Ph Eur, BP, NF, FCC, E 304 Conforms to the purity criteria on food additives according to the European Commission directive 96/77/EC | |
