Benzonase® endonuclease
The intelligent DNA removal solution for biopharmaceutical production
There is only one effective biochemical method to remove DNA and RNA, both in the laboratory and in industrial scale processes: Benzonase® endonuclease from Merck.
The challenge: DNA impurities in biopharmaceuticals
Currently, already more than 250 therapeutic proteins are approved for use in humans. Optimistic estimates predict that by 2015, around one-half of all newly developed drugs will be biopharmaceuticals. These new types of drug pose new challenges to manufacturers not least in terms of drug safety. Since biotech drugs are manufactured using microorganisms, it is important to avoid DNA impurities by thoroughly removing DNA from the product. International guidelines governing the manufacture of recombinant therapeutics limit the maximum nucleic acid contamination to 10 pg per dose.
The smart solution: Benzonase®
Benzonase®, a unique, genetically engineered endonuclease specifically developed for use in biotechnology, offers a variety of advantages over competing methods of nucleic acid removal. The advanced production techniques used to manufacture Benzonase® endonuclease ensure a product of exceptionally high purity and activity, without measurable protease activity, and without viral contaminants that can accompany enzymes isolated from natural sources. Using Benzonase, you are able to meet the highest possible purity standards for biopharmaceuticals.
Your benefits at a glance:
Benzonase® endonuclease
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| Exceptionally high purity |
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| To meet a wide range of processing and cost requirements, Benzonase® endonuclease is available in different grades of purity: |
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Benzonase® suited for a variety of applications
Benzonase® endonuclease has proven its value in the laboratory for over fifteen years and is now successfully applied in many production processes throughout the pharmaceutical and biotechnological industry. It can be used in different fields of application from product quality assurance to particle processing to bioanalytical applications.
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If you need enzymes of the highest quality, purity, and activity, as well as the assurance to meet all regulatory requirements, then you need Benzonase® endonuclease from Merck.
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| Frequently Asked Questions about Benzonase® endonuclease |
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