100085
Acetylsalicylic acid
suitable for use as an active pharmaceutical ingredient BP,Ph Eur,USP
| Product information | |||
|---|---|---|---|
| Grade | BP,Ph Eur,USP | ||
| Synonyms | Acetoxybenzoic acid | ||
| Formula Hill | C9H8O4 | ||
| HS Code | 2918 22 00 | ||
| EC number | 200-064-1 | ||
| Molar mass | 180.15 g/mol | ||
| CAS number | 50-78-2 | ||
| Chemical and physical data | |||
|---|---|---|---|
| Ignition temperature | 500 °C DIN 51794 | ||
| Solubility | 3.3 g/l (20 °C) | ||
| Melting point | 136 °C | ||
| Molar mass | 180.15 g/mol | ||
| Density | 1.35 g/cm3 (20 °C) | ||
| pH value | 3.5 (2.5 g/l, H2O, 20 °C) | ||
| Flash point | 250 °C DIN 51755 Part 1 | ||
| Safety information | |||
|---|---|---|---|
| R Phrase |
R 22 Harmful if swallowed. |
||
| Categories of danger | harmful | ||
| Hazard Symbol |
|
||
| Storage class | 10 - 13 Other liquids and solids | ||
| WGK | WGK 1 slightly water endangering | ||
| Disposal |
3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
||
| Toxicological data | |||
|---|---|---|---|
| LD 50 oral | LD50 rat 1124 - 1228 mg/kg | ||
| Specifications | |
|---|---|
| Assay - Ph.Eur., calculated on dried substance | 99.5 - 101.0 % |
| - USP, calculated on dried substance | 99.5 - 100.5 % |
| Identity | passes test |
| Appearance of solution (10 %; ethanol 96 %) | passes test |
| Substances insoluble in sodium carbonate | passes test |
| Salicylic acid | ≤ 0.05 % |
| Chloride (Cl) | ≤ 0.01 % |
| Sulphate (SO4) | ≤ 0.02 % |
| Heavy metals (as Pb) | ≤ 0.001 % |
| Related substances (HPLC) | passes test |
| Residual solvents (Ph. Eur./USP/ICH) of class 3 | ≤ 0.5 % |
| Other residual solvents (Ph. Eur./USP/ICH) | excluded by production process |
| Readily carbonisable substance | passes test |
| Sulfated ash | ≤ 0.05 % |
| Loss on drying | ≤ 0.5 % |
| Corresponds to Ph Eur, BP, USP | |
