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15 February 2012
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A cell-permeable porphyrin compound that binds STAT3 (KD = 880 nM by SPR) and prevents STAT3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 µM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC50 = 10 µM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 µM. One day 5,15-DPP pre-treatment (50 µM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced STAT3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear STAT3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 462.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C32H22N4 | ||
| CAS number | 22112-89-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
