566330
SIRT1/2 Inhibitor VIII, Salermide
N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
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15 February 2012
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A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Molar mass | 394.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C26H22N2O2 | ||
| CAS number | 1105698-15-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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