557508
Ro-31-7549
2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
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Merck KGaA
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64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
15 February 2012
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A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
| Product information | |||
|---|---|---|---|
| Form | Red to reddish-orange solid | ||
| Primary Target | rat brain PKC | ||
| Primary Target IC50 | 158 nM | ||
| Secondary target | IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε. Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM). | ||
| Molar mass | 458.5 | ||
| Protect from Light | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO | ||
| Chemical formula | C24H22N4O2 · C2H4O2 | ||
| CAS number | 125313-65-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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