557401
RNA-Editing Ligase 1 Inhibitor, NSC 45208
4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
15 February 2012
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A sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
| Product information | |||
|---|---|---|---|
| Form | Dark red solid | ||
| Molar mass | 590.48 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% based on elemental analysis | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C20H12N2Na2O8S2 • 4H2O | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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