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15 February 2012
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Suitable for the in vitro quantitation of mutant and wild-type p53 protein.
The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer with the majority of mutations being amino acid substitutions. p53 is targeted for inactivation by transforming viral oncoproteins. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage.
| Product information | |||
|---|---|---|---|
| Format | 96-well plate | ||
| Form | 96 Tests | ||
| Detection method | Colorimetric | ||
| Species reactivity | human | ||
| Do not freeze | Yes | ||
| Specificity | Mutant and wild-type p53 | ||
| Sensitivity | 10 pg/ml | ||
| Assay range | 93.75 - 1500 pg/ml | ||
| Assay time | Overnight | ||
| Sample type | Cell extracts, tissue extracts, conditioned media, sera, urine | ||
| Kit contains | Anti-Panp53 Coated 96-Well Plate, 2 vials of Lyophilized Standards, Reporter Antibody Peroxidase Conjugate, Normal Mouse Serum (Cat. No. NS03L), Antigen Extraction Agent, Peroxidase Substrate, Diluents, Buffers, Stop Solution, and a user protocol. | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +2°C to +8°C | ||
| Ship |
Blue Ice Only
Multiple Toxicity Values, refer to MSDS |
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