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Merck KGaA
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15 febrero 2012
cargando
An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
| Producto alternativo | |
|---|---|
| 459620 | Okadaic Acid, Sodium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459618 | Okadaic Acid, Potassium Salt |
| Productos alternativos para Okadaic Acid, Prorocentrum sp. | |
| 459620 | Okadaic Acid, Sodium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459618 | Okadaic Acid, Potassium Salt |
| Accesorios paraOkadaic Acid, Prorocentrum sp. |
| Información sobre producto | |||
|---|---|---|---|
| Form | Colorless glassy solid | ||
| Primary Target | protein phosphatase | ||
| Primary Target IC50 | 10-15 nM | ||
| Secondary target | protein phosphatse 2A (IC50 = 0.1 nM) | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C44H68O13 | ||
| RTECS | AA8227800 | ||
| Número CAS | 78111-17-8 | ||
| Merck USA index | 14, 6819 | ||
| Almacenar y enviar información | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Categoría de alamacenamiento | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 22-26-36/37/39-45 |
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| Frase R |
R: 23/24/25-38 |
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