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Merck KGaA
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15 February 2012
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An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
| Alternatives | |
|---|---|
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| 459618 | Okadaic Acid, Potassium Salt |
| Alternative products for Okadaic Acid, Prorocentrum sp. | |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| 459618 | Okadaic Acid, Potassium Salt |
| Accessories forOkadaic Acid, Prorocentrum sp. |
| Product information | |||
|---|---|---|---|
| Form | Colorless glassy solid | ||
| Primary Target | protein phosphatase | ||
| Primary Target IC50 | 10-15 nM | ||
| Secondary target | protein phosphatse 2A (IC50 = 0.1 nM) | ||
| Molar mass | 805.0 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | MeOH, EtOH, DMF, CHCl3 | ||
| Chemical formula | C44H68O13 | ||
| RTECS | AA8227800 | ||
| CAS number | 78111-17-8 | ||
| Merck USA index | 14, 6819 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
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| S Phrase |
S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25-38 Toxic by inhalation, in contact with skin and if swallowed. Irritating to skin. |
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