420120
Juglone
5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
14 Februar 2012
wird geladen
A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
| Produktinformationen | |||
|---|---|---|---|
| Form | Orange solid | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥95% by HPLC | ||
| Chemische Formel | C10H6O3 | ||
| RTECS | QJ5775000 | ||
| CAS-Nummer | 481-39-0 | ||
| Merck USA index | 14, 5269 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 45-26 |
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| R-Satz |
R: 36/37/38-25 |
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