420139
JAK2 Inhibitor IV
3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
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Merck KGaA
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64293 Darmstadt
Germany
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15 febrero 2012
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An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
| Información sobre producto | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥97% by HPLC | ||
| Fórmula químico | C17H20N4O2S | ||
| Número CAS | 1110502-30-1 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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