382172
Histone Deacetylase Inhibitor VI, HNHA
N-Hydroxy-7-(2-naphthylthio)heptanomide
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
15 Februar 2012
wird geladen
A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
| Produktinformationen | |||
|---|---|---|---|
| Form | White solid | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥95% by HPLC | ||
| Chemische Formel | C17H21NO2S | ||
| CAS-Nummer | 926908-04-5 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-24/25-36/37/39 |
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| R-Satz |
R: 36/37/38 |
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