324732
ErbB2 Inhibitor II
4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
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Merck KGaA
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64293 Darmstadt
Germany
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15 febrero 2012
cargando
A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
| Información sobre producto | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C15H10N4O | ||
| Número CAS | 928207-02-7 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-36-45 |
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| Frase R |
R: 36/37/38 |
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