324683
Ellagic Acid, Dihydrate
4,4′,5,5′,6,6′-Hexahydroxydiphenic Acid 2,6,2′,6′-Dilactone, TBBD
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Teléfono: +49 6151 72-0
Fax: +49 6151 72 2000
15 febrero 2012
cargando
A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
| Información sobre producto | |||
|---|---|---|---|
| Form | Slightly Beige Powder | ||
| Primary Target | CDK2 | ||
| Primary Target IC50 | 40 nM | ||
| Secondary target | DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively) | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥98% by HPCE | ||
| Fórmula químico | C14H6O8 · 2H2O | ||
| RTECS | DJ2620000 | ||
| Número CAS | 476-66-4 | ||
| Merck USA index | 14, 3547 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-36 |
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| Frase R |
R: 36/37/38 |
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