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Merck KGaA
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64293 Darmstadt
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15 febrero 2012
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An antitumor agent and protein kinase C (PKC) inhibitor. When exposed to UV light, DECA covalently binds to and irreversibly inhibits PKCα and PKCβ (IC50 = 7-18 µM). A potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 µM). A blocker of ganglionic transmission (EC50 = 2 µM). Selectively accumulates within the mitochondria of carcinoma cells and disrupts energy production.
| Información sobre producto | |||
|---|---|---|---|
| Form | White powder with a dark yellow cast | ||
| Primary Target | PKCα, PKCβ | ||
| Primary Target IC50 | 7-18 µM | ||
| Secondary target | Ca2+-activated K+ channel (IC50 = 1.1 µM) | ||
| Purity | ≥95% by titration | ||
| Fórmula químico | C30H40Cl2N4 | ||
| RTECS | VA0700000 | ||
| Número CAS | 522-51-0 | ||
| Merck USA index | 14, 2913 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-36 |
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| Frase R |
R: 36/37/38 |
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