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15 febrero 2012
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A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control.
| Información sobre producto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | Hh signaling in Shh-light2 assay | ||
| Primary Target IC50 | 20 nM | ||
| Secondary target | in P2Ptch-/-cells (IC50 = 50 nM) | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Cell permeable | Si | ||
| Purity | ≥97% by HPLC | ||
| Fórmula químico | C27H41NO2 | ||
| RTECS | GY0750000 | ||
| Número CAS | 4449-51-8 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |
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