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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Teléfono: +49 6151 72-0
Fax: +49 6151 72 2000
15 febrero 2012
cargando
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions.
| Información sobre producto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | hFKBP12 | ||
| Primary Target Ki | 3.4 µM | ||
| Purity | ≥98% by HPLC | ||
| Fórmula químico | C15H23NO4 | ||
| RTECS | MA4375000 | ||
| Número CAS | 66-81-9 | ||
| Merck USA index | 14, 2728 | ||
| Almacenar y enviar información | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Categoría de alamacenamiento | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 45-53-61 |
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| Frase R |
R: 28-40-51/53-61 |
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