Wenn Sie allgemeine Fragen haben, wenden Sie sich bitte an unseren Kundenservice:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
15 Februar 2012
wird geladen
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions.
| Produktinformationen | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | hFKBP12 | ||
| Primary Target Ki | 3.4 µM | ||
| Purity | ≥98% by HPLC | ||
| Chemische Formel | C15H23NO4 | ||
| RTECS | MA4375000 | ||
| CAS-Nummer | 66-81-9 | ||
| Merck USA index | 14, 2728 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
|
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
|||
| Lagerkategorie | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 45-53-61 |
||
| R-Satz |
R: 28-40-51/53-61 |
||
