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15 February 2012
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Native, human C3a complement component. Single chain, 77 amino acid peptide. Activation of either complement pathway can result in formation of C3-cleaving enzymes (C3 convertases) on target surfaces. The C3 convertase enzymes of either complement activation pathway will cleave the C3 α-chain at peptide bond 77 resulting in the production and release of the C3a peptide. C3a, one of the three complement-derived anaphylatoxins, expresses a wide variety of biological activities which include smooth muscle contraction, platelet and neutrophil activation and aggregation, skin wheal and flare, and immunoregulatory reactions.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In PBS, pH 7.2, sterile-filtered through a 0.22 µm filter. | ||
| Molar mass | 9083 | ||
| Avoid freeze/thaw | Yes | ||
| Purity | ≥95% by SDS-PAGE | ||
| Contaminants | C3adesArg; ≤10% | ||
| Source | Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
||
