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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
15 Februar 2012
wird geladen
Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
| Produktinformationen | |||
|---|---|---|---|
| Form | Light yellow to yellow solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 660 nM | ||
| Cell permeable | Ja | ||
| Purity | ≥97% by NMR | ||
| Chemische Formel | C21H18NO4Cl | ||
| RTECS | FL9200000 | ||
| CAS-Nummer | 3895-92-9 | ||
| Merck USA index | 14, 2051 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 26-36 |
||
| R-Satz |
R: 20/21/22-36/37/38 |
||
