227016
CCR2 Antagonist
2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
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15 febrero 2012
cargando
A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
| Información sobre producto | |||
|---|---|---|---|
| Form | White solid | ||
| Protect from Light | Si | ||
| Hygrocopic | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥97% by HPLC (racemic mixture) | ||
| Fórmula químico | C28H34F3N5O4S | ||
| Número CAS | 445479-97-0 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 22-24/25-36/37/39 |
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