219013
Caspase-3 Inhibitor VIII
N-Benzyloxycarbonyl-(S)-tert-butyl-Leu-Asp-Aldehyde, Z-tLD-CHO
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
15 Februar 2012
wird geladen
A cell-permeable dipeptidyl aspartic aldehyde that potently inhibits caspase-3 activity (Ki0 = 3.6 nM) in a reversible and substrate-competitive manner. Z-tLeu-Asp-H, at a concentration of ≥0.43 nM, is shown to completely inhibit the vitamine E-induced PARP cleavage in human DLD-1 colon adenocarcinoma cells, while the activation of caspase-3 by its upstream caspases is not affected.
| Produktinformationen | |||
|---|---|---|---|
| Peptide Sequence | Z-tertLeu-Asp-H | ||
| Form | Lyophilized solid | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥97% by HPLC | ||
| Chemische Formel | C18H24N2O6 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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