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Merck KGaA
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15 February 2012
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Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
| Product information | |||
|---|---|---|---|
| Form | White to off-white solid | ||
| Hygrocopic | Yes | ||
| Biological activity | Potency: 1.5-2.0 U/mg | ||
| Purity | ≥90% by HPLC (A2 + B2) | ||
| Solubility | H2O | ||
| RTECS | EC5991990 | ||
| CAS number | 9041-93-4 | ||
| Merck USA index | 14, 1318 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 20/21/22-36/37/38-40-42/43 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact. |
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