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15 February 2012
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A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP).
Note: 1 set = 3 x 10 µg
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | vacuolar type H+ ATPase | ||
| Primary Target IC50 | 500 pM | ||
| Molar mass | 622.8 | ||
| Protect from Light | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C35H58O9 | ||
| CAS number | 88899-55-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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