189497
Autophagy Inducer, STF-62247
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
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Merck KGaA
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64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
15 febrero 2012
cargando
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
| Información sobre producto | |||
|---|---|---|---|
| Form | Beige solid | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C15H13N3S | ||
| Número CAS | 315702-99-9 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-39 |
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| Frase R |
R: 22-41 |
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