662087
UCH-L1, His•Tag® , Mouse, Recombinant, E. coli
Ubiquitin C-terminal Hydrolase L1, Ubiquitin thioesterase L1
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
14 February 2012
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Full-length, recombinant, mouse UCHL-1 fused at the N-terminus to His•Tag® sequence and expressed in E. coli. UCH-L1 is a member of the low molecular weight UCHs that processes ubiquitin precursors and ubiquitinated proteins to generate monomeric ubiquitin. The expression of UCH-L1 is highly specific to cells of the neuroendocrine system and their tumors. UCH-L1 variants (Ile93Met) have been linked to Parkinson disease and may participate in processes critical for neuronal health. The active enzyme is useful in the study of ubiquitin regulation and inhibitor screening.
| Product information | |||
|---|---|---|---|
| Formulation | In 50 mM HEPES, 2 mM DTT, pH 8.0. | ||
| Molar mass | 25000 | ||
| Avoid freeze/thaw | Yes | ||
| Purity | ≥95% by SDS-PAGE | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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