662040
Pro-SUMO-3, Human, Recombinant, E. coli
SUMO-3, Ubiquitin-like protein SMT3A, SMT3 homolog 1, SUMO-2
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
14 February 2012
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Full Length, recombinant, human pro-SUMO-3 expressed in E. coli. SUMOylation results in altered subcellular localization of target proteins involved in cell cycle, transcription, cell death, and stress response, as well as membrane-associated receptors, and viral proteins. Pro-SUMOs are processed by SENPs (endopeptidase cleavage) to remove short C-terminal extensions revealing the Gly-Gly motif that is essential for substrate conjugation to target proteins. Pro-SUMO-3 (103 amino acids) is the inactive precursor of SUMO-3 (92 amino acids) and is processed at the C-terminus by SENPs. The protein can be used as a substrate for SENPs or as a negative control in sumoylation reactions.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 150 mM NaCl, 50 mM HEPES, 1 mM DTT, pH 8.0. | ||
| Molar mass | 11600 | ||
| Avoid freeze/thaw | Yes | ||
| Purity | ≥95% by SDS-PAGE | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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