A cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC50 = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC50 ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 1 mM (50 µg/82 µl) solution in DMSO. | ||
| Primary Target | PP1 | ||
| Primary Target IC50 | 1.6 nM | ||
| Secondary target | PP2A (IC50 = 62 nM) | ||
| Molar mass | 606.7 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Chemical formula | C33H50O10 | ||
| RTECS | WX0900000 | ||
| CAS number | 119757-73-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Flammable |
||
