A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | antagonist of the Shh (Sonic Hedgehog) signaling pathway | ||
| Primary Target IC50 | 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells | ||
| Secondary target | activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay) | ||
| Molar mass | 373.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C23H27N5 | ||
| CAS number | 304909-07-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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