A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
| Product information | |||
|---|---|---|---|
| Form | Orange solid | ||
| Primary Target | PKCδ | ||
| Primary Target IC50 | 3-6 µM | ||
| Secondary target | PKCα, PKCβ, and PKCγ (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM) | ||
| Molar mass | 516.5 | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C30H28O8 | ||
| RTECS | AM6913800 | ||
| CAS number | 82-08-6 | ||
| Merck USA index | 14, 8272 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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