A decapeptide derived from the N-terminal MDM-2 binding domain of p53, residues 17 - 26, and linked to the Antennapedia leader sequence at the C-terminal. Exerts anti-proliferative activities. Directly binds to MDM-2 and induces non-apoptotic cell-death (IC50 = 40 µg/ml in TUC-3 cells) that is independent of p53 activation. Reported to have no effect on the growth of normal cells.
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Product information
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Peptide Sequence
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H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
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Form
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Lyophilized
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Formulation
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Supplied as a trifluoacetate salt.
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Molar mass
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3509.2
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Protect from Light
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Yes
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Hygrocopic
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Yes
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Packaged under inert gas
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Yes
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Purity
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≥95% by HPLC
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Solubility
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H2O
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Chemical formula
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C164H255N47O37S
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Store and ship information
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Storage
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-20°C
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Ship
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Blue or Dry Ice
Standard Handling
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