506136
p53, MDM-2 Binding Domain, N-Terminal 17-26, Cell-Permeable
PNC-28, ETFSDLWKLL-KKWKMRRNQFWVKVQRG
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Merck KGaA
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14 February 2012
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A decapeptide derived from the N-terminal MDM-2 binding domain of p53, residues 17 - 26, and linked to the Antennapedia leader sequence at the C-terminal. Exerts anti-proliferative activities. Directly binds to MDM-2 and induces non-apoptotic cell-death (IC50 = 40 µg/ml in TUC-3 cells) that is independent of p53 activation. Reported to have no effect on the growth of normal cells.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH | ||
| Form | Lyophilized | ||
| Formulation | Supplied as a trifluoacetate salt. | ||
| Molar mass | 3509.2 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C164H255N47O37S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
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