475843
Minocycline, Hydrochloride
7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
14 February 2012
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Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
| Product information | |||
|---|---|---|---|
| Form | Dark yellow solid | ||
| Molar mass | 493.9 | ||
| Purity | ≥98% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C23H27N3O7 · HCl | ||
| RTECS | QI7630500 | ||
| CAS number | 13614-98-7 | ||
| Merck USA index | 14, 6202 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-45-36 Do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing. |
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| R Phrase |
R: 33-36/37/38-63-64 Danger of cumulative effects. Irritating to eyes, respiratory system and skin. Possible risk of harm to the unborn child. May cause harm to breastfed babies. |
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