Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized pale-yellow solid | ||
| Primary Target | PP1 | ||
| Primary Target IC50 | 1.7 nM | ||
| Secondary target | PP2A (IC50 = 40 pM) | ||
| Molar mass | 995.2 | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C49H74N10O12 | ||
| RTECS | GT2810000 | ||
| CAS number | 101043-37-2 | ||
| Declaration | Not available for sale outside of the United States. | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic |
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| End use certificate | To purchase this product, the completion of a "Select Agent Declaration" and/or "End-Use Certificate" is required. Once your sales order is placed, our Regulatory Specialist will be contacting the end-user of this product to complete the required form(s). Please ensure to provide the customer service representative with the end-user's name, telephone number, fax number and e-mail address to prevent delivery delays. (Note: the completed form must be returned within five (5) business days from receipt and will be valid for one year from the date of signing.) | ||
| Safety information | |||
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| S Phrase |
S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 26/27/28-36/37/38-43 May cause sensitization by skin contact. |
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