An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
|
Product information
|
|
Form
|
White solid
|
|
Molar mass
|
331.4
|
|
Protect from Light
|
Yes
|
|
Packaged under inert gas
|
Yes
|
|
Purity
|
≥98% by NMR
|
|
Solubility
|
DMSO
|
|
Chemical formula
|
C15H29N3O5
|
|
CAS number
|
154039-60-8
|
|
Store and ship information
|
|
|
|
Storage
|
+2°C to +8°C
|
|
Ship
|
Ambient Temperature Only
Standard Handling
|
|
Safety information
|
|
S Phrase
|
S: 22-24/25-36/37/39
Do not breathe dust.
|