A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC50 = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC50 = 1.0 and 1.6 µM, respectively). Shown to reduce LPS-induced TNF-α production in PBMCs (IC50 = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 261.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C12H11N3O2S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-24/25-36 Do not breathe dust. Wear suitable protective clothing. |
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