A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. Inhibits protein kinase A (Ki = 3.0 µM), myosin light chain kinase (Ki = 97 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
| Product information | |||
|---|---|---|---|
| Form | Light yellow lyophilized solid | ||
| Primary Target | MLCK | ||
| Primary Target Ki | Ki = 97 µM | ||
| Secondary target | protein kinase A (Ki = 3.0 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM) | ||
| Molar mass | 364.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C14H17N3O2S · 2HCl | ||
| CAS number | 108930-17-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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