A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC). Inhibits protein kinase A (IC50 = 510 nM), protein kinase G (IC50 = 4.8 µM), and myosin light chain kinase (IC50 = 120 nM) at much higher concentrations.
| Product information | |||
|---|---|---|---|
| Form | Amber solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 4 nM | ||
| Secondary target | MLCK (IC50 = 120 nM), PKA (IC50 = 150 nM) | ||
| Molar mass | 507.0 | ||
| Protect from Light | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C27H26N4O4 · HCl | ||
| Declaration | Sold under license of U.S. Patent 5,489,608 and European Patent 0,434,057. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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