365251
Gö 6983
2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
14 February 2012
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A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
| Product information | |||
|---|---|---|---|
| Form | Orange red solid | ||
| Primary Target | PKCα and PKCβ | ||
| Primary Target IC50 | 7 nM | ||
| Secondary target | IC50 = 6 nM for PKCγ, 10 nM for PKCδ, and 60 nM for PKCζ | ||
| Molar mass | 442.5 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C26H26N4O3 | ||
| CAS number | 133053-19-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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