Aminoglycoside related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial
neor/
kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
Also available as a sterile-filtered solution (Cat. No.
345812).
| Accessories for G 418 Sulfate, Cell Culture Tested |
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Product information
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Form
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Crystalline solid
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Molar mass
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692.7
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Biological activity
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Potency: ≥730 µg/mg
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Purity
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≥98% by TLC
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pH value
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4.0 -6.0
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Solubility
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Aqueous buffers or H2O
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Chemical formula
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C20H40N4O10 · 2H2SO4
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RTECS
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CB9378500
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CAS number
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108321-42-2
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Store and ship information
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Storage
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+15°C to +30°C
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Ship
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Ambient Temperature Only
Standard Handling
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