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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
14 February 2012
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A cell-permeable, specific inhibitor of protein phosphatase 2A (PP2A, IC50 = 90 nM). Exhibits only a weak effect on PP1 (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | PP2A | ||
| Primary Target IC50 | 90 nM | ||
| Secondary target | PP1 (IC50 = 5 µM) | ||
| Molar mass | 186.2 | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C8H10O5 | ||
| RTECS | RN7875000 | ||
| CAS number | 145-73-3 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 21-25-36/37/38 Harmful in contact with skin. Toxic if swallowed. Irritating to eyes, respiratory system and skin. |
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