Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | hFKBP12 | ||
| Primary Target Ki | 3.4 µM | ||
| Molar mass | 281.3 | ||
| Purity | ≥98% by HPLC | ||
| Solubility | EtOH or MeOH | ||
| Chemical formula | C15H23NO4 | ||
| RTECS | MA4375000 | ||
| CAS number | 66-81-9 | ||
| Merck USA index | 14, 2728 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 45-53-61 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. Avoid release to the environment. Refer to special instructions/safety data sheet. |
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| R Phrase |
R: 28-40-51/53-61 Very toxic if swallowed. Limited evidence of a carcinogenic effect. May cause harm to the unborn child. |
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