A cell-permeable brominated benzimidazolo compound that acts as a potent, high affinity and ATP-competitive inhibitor of CK2 (IC
50 = 140 nM for rat liver CK2; K
i = 40 nM). Displays ~1300 fold greater selectivity over CK1 (IC
50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No.
218697). Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1a) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Shown to induce apoptosis in Jurkat T cells at 2.5 µM. A 10 mM (5 mg/1.05 ml) solution of Casein Kinase II Inhibitor, DMAT (
Cat. No. 218706), in DMSO is also avialable.
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Product information
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Form
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White solid
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Primary Target
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CK2
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Primary Target IC50
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140 nM
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Secondary target
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CK2 Ki = 40 nM, CK1 (IC50 > 200 µM)
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Molar mass
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476.8
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Protect from Light
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Yes
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Packaged under inert gas
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Yes
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Cell permeable
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Yes
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ATP Competitive
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Yes
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Purity
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≥95% by HPLC
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Solubility
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DMSO
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Chemical formula
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C9H7Br4N3
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CAS number
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749234-11-5
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Store and ship information
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Storage
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+2°C to +8°C
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Ship
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Ambient Temperature Only
Standard Handling
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