A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | PP2A | ||
| Primary Target IC50 | 0.5-1 nM | ||
| Secondary target | PP1 (IC50 = 2 nM) | ||
| Molar mass | 1009.2 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C50H81N4O15P | ||
| CAS number | 101932-71-2 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25-38 Irritating to skin. |
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